Turtzo L Christine, McCullough Louise D
Department of Neurology and Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA.
Cerebrovasc Dis. 2008;26(5):462-74. doi: 10.1159/000155983. Epub 2008 Sep 23.
Increasing evidence suggests that sex differences exist in the etiology, presentation, treatment, and outcome from stroke. The reasons for these sex disparities are becoming increasingly explored, but large gaps still exist in our knowledge. Experimental studies over the past several years have demonstrated intrinsic sex differences both in vivo and in animal models which may have relevance to our understanding of stroke in clinical populations. A greater understanding of the differences and similarities between males and females with respect to the risk factors, pathophysiology, and response to stroke will facilitate the design of future clinical trials and enhance the development of treatment strategies to improve stroke care in both sexes. This article reviews the current literature on sex differences in stroke with an emphasis on the clinical data, incorporating an analysis of bench research as it pertains to the bedside.
越来越多的证据表明，中风的病因、表现、治疗和预后存在性别差异。人们对这些性别差异的原因进行了越来越多的探索，但我们的认识仍存在很大差距。过去几年的实验研究表明，在体内和动物模型中都存在内在的性别差异，这可能与我们对临床人群中风的理解有关。更好地了解男性和女性在中风危险因素、病理生理学和反应方面的异同，将有助于未来临床试验的设计，并促进治疗策略的发展，以改善两性的中风护理。本文回顾了目前关于中风性别差异的文献，重点关注临床数据，并结合了与临床相关的基础研究分析。
