基于异腈的新型三组分一锅法合成氰基苯基氨基乙酰胺衍生物

Novel isocyanide-based three-component one-pot synthesis of cyanophenylamino-acetamide derivatives.

作者信息

Shaabani Ahmad, Maleki Ali, Mofakham Hamid, Khavasi Hamid Reza

机构信息

Department of Chemistry, Shahid Beheshti UniVersity, P.O. Box 19396-4716, Tehran, Iran.

出版信息

J Comb Chem. 2008 Nov-Dec;10(6):883-5. doi: 10.1021/cc800099r. Epub 2008 Sep 24.

DOI:10.1021/cc800099r

PMID:18811217

Abstract

A one-pot multicomponent synthesis of a novel class of cyanophenylamino-acetamides through the conversion of primary amides to the corresponding nitriles, starting from simple and readily available inputs including 2-aminobenzamide, an aldehyde, and an isocyanide in the presence of p-toluenesulfonic acid as a catalyst, in excellent yields at room temperature in ethanol as a green reaction medium is described.

摘要

描述了一种一锅多组分合成新型氰基苯基氨基乙酰胺的方法，该方法通过将伯酰胺转化为相应的腈来实现，起始原料简单易得，包括2-氨基苯甲酰胺、一种醛和一种异腈，在对甲苯磺酸作为催化剂的存在下，于室温下在乙醇作为绿色反应介质中以优异的产率进行反应。