Shaabani Ahmad, Maleki Ali, Hajishaabanha Fatemeh, Mofakham Hamid, Seyyedhamzeh Mozhdeh, Mahyari Mojtaba, Ng Seik Weng
Department of Chemistry, Shahid Beheshti University, Tehran, Iran.
J Comb Chem. 2010 Jan-Feb;12(1):186-90. doi: 10.1021/cc900125a.
In this work, two novel isocyanide-based multicomponent reactions of 1,2-diamine compounds with diketene have been developed as efficient strategies for the synthesis of 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-2-carboxamides with regiochemical control and 1,6-dihydropyrazine-2,3-dicarbonitriles in good to excellent yields at ambient temperature.
在本研究中，已开发出两种基于异腈的新型多组分反应，即1,2 - 二胺化合物与双乙烯酮的反应，作为在室温下以区域化学控制合成2,3,4,5 - 四氢-1H - 苯并[b][1,4]二氮杂卓-2 - 甲酰胺以及以良好至优异产率合成1,6 - 二氢吡嗪-2,3 - 二甲腈的有效策略。
