基于异腈的四氢苯并[b][1,4]恶唑并庚因和丙二酰胺衍生物的新型一锅多组分合成法。
Novel isocyanide-based one-pot multicomponent syntheses of tetrahydrobenzo[b][1,4]oxazepine and malonamide derivatives.
作者信息
Shaabani Ahmad, Mofakham Hamid, Maleki Ali, Hajishaabanha Fatemeh
机构信息
Department of Chemistry, Shahid Beheshti University, G. C., P.O. Box 19396-4716, Tehran, Iran.
出版信息
J Comb Chem. 2010 Sep 13;12(5):630-2. doi: 10.1021/cc100032d.
PMID:20831262
Abstract
In this work, a novel one-pot multicomponent reaction of 2-aminophenols, Meldrum's acid, and isocyanides leads to the synthesis of tetrahydrobenzo[b][1,4]oxazepine or malonamide derivatives using 1 or 2 equiv of 2-aminophenols, respectively, in good to excellent yields at ambient temperature.
摘要
在本研究中，2-氨基酚、丙二酸亚异丙酯和异腈发生新型一锅多组分反应，分别使用1或2当量的2-氨基酚，在室温下以良好至优异的产率合成四氢苯并[b][1,4]噁氮杂卓或丙二酰胺衍生物。
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