Sitjà-Bobadilla A
Instituto de Acuicultura de Torre de la Sal, Consejo Superior de Investigaciones Científicas, Torre de la Sal s/n, 12595 Ribera de Cabanes, Castellón, Spain.
Parasite. 2008 Sep;15(3):420-5. doi: 10.1051/parasite/2008153420.
Myxozoan parasites are responsible for important economic losses among fisheries and aquaculture industries, and hence the high interest in studying the immune response of fish against them. The most important data available concerning the immune response of fish against myxosporeans are reviewed, with emphasis on the different innate and adaptive immune mechanisms, their relationship with natural and acquired resistance and the strategies to control and prevent myxosporoses. Cellular effectors (lymphocytes, granulocytes, phagocytes, non-specific cytotoxic cells, rodlet cells) and humoral factors (lysozyme, peroxidades, antiproteases, complement, specific antibodies) have been examined for several myxosporoses, and some immune relevant genes have been studied. This information will be crucial for the future development of vaccines and other preventive strategies such as immunomodulation and selection of disease-resistant strains
黏孢子虫寄生虫给渔业和水产养殖业造成了重大经济损失，因此人们对研究鱼类针对它们的免疫反应兴趣浓厚。本文综述了有关鱼类针对黏孢子虫免疫反应的最重要现有数据，重点关注不同的固有免疫和适应性免疫机制、它们与天然抗性和获得性抗性的关系以及控制和预防黏孢子虫病的策略。针对几种黏孢子虫病，研究了细胞效应器（淋巴细胞、粒细胞、吞噬细胞、非特异性细胞毒性细胞、刺丝囊细胞）和体液因子（溶菌酶、过氧化物酶、抗蛋白酶、补体、特异性抗体），并对一些与免疫相关的基因进行了研究。这些信息对于疫苗及其他预防策略（如免疫调节和抗病品系的选育）的未来发展至关重要。
