潜在暴露但未感染的个体产生细胞毒性和多功能的1型人类免疫缺陷病毒特异性CD8(+) T细胞反应，这些反应可以在表位水平上进行定义。
Potentially exposed but uninfected individuals produce cytotoxic and polyfunctional human immunodeficiency virus type 1-specific CD8(+) T-cell responses which can be defined to the epitope level.
作者信息
Erickson A L, Willberg C B, McMahan V, Liu A, Buchbinder S P, Grohskopf L A, Grant R M, Nixon D F
机构信息
Division of Experimental Medicine, Department of Medicine, UCSF, San Francisco, CA 94110, USA.
出版信息
Clin Vaccine Immunol. 2008 Nov;15(11):1745-8. doi: 10.1128/CVI.00247-08. Epub 2008 Sep 24.
Abstract
We measured CD8(+) T-cell responses in 12 potentially exposed but uninfected men who have sex with men by using cytokine flow cytometry. Four of the individuals screened exhibited polyfunctional immune responses to human immunodeficiency virus type 1 Gag or Vif. The minimum cytotoxic T lymphocyte epitope was mapped in one Gag responder.
摘要
我们通过细胞因子流式细胞术检测了12名有男男性行为且有潜在暴露风险但未感染的男性的CD8(+) T细胞反应。在筛查的个体中，有4人对1型人类免疫缺陷病毒（HIV-1）的Gag或Vif表现出多功能免疫反应。在一名对Gag有反应者中确定了最小细胞毒性T淋巴细胞表位。
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