Zhao Hai-Lu, Sui Yi, Guan Jing, He Lan, Lai Fernand M M, Zhong Ding-Rong, Yang Di, Baum Larry, Tong Peter C Y, Tomlinson Brian, Chan Juliana C N
Departments of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Pancreas. 2008 Oct;37(3):e68-73. doi: 10.1097/MPA.0b013e3181788e18.
Type 2 diabetes mellitus is characterized histopathologically by islet amyloid deposits formed from islet amyloid polypeptide. The aim of this study was to investigate sex difference in islet amyloid of type 2 diabetic patients.
Pancreas specimens were collected from 235 autopsies with type 2 diabetes mellitus. Islet amyloid was identified with Congo red stain. The load of islet amyloid deposits was assessed by prevalence (percentage of cases with islet amyloid deposits), frequency (percentage of islets containing amyloid deposits), and severity (percentage of islet area occupied by amyloid deposits).
Women (n = 80) and men (n = 155) had similar age of death, duration of diabetes, body mass index, and hemoglobin (Hb)A1c level. Islet amyloid was found in 30.0% of the women and in 44.5% of the men (P = 0.035). None of 9 women younger than 50 years had islet amyloid. Frequency of amyloid-affected islets was 31.5% +/- 13.1% in women and 41.1% +/- 14.3% in men (P = 0.008). Severity of amyloid-affected islet area was 29.0% +/- 12.5% in women and 38.5% +/- 14.6% in men (P = 0.007).
Sex is a determinant of the development of islet amyloid in type 2 diabetes mellitus. This sex difference in islet amyloid may be related to a potential benefit of female sex hormones.
2型糖尿病在组织病理学上的特征是由胰岛淀粉样多肽形成的胰岛淀粉样沉积。本研究的目的是调查2型糖尿病患者胰岛淀粉样变的性别差异。
收集235例2型糖尿病患者的胰腺尸检标本。用刚果红染色鉴定胰岛淀粉样变。通过患病率（有胰岛淀粉样沉积病例的百分比）、频率（含有淀粉样沉积的胰岛的百分比）和严重程度（淀粉样沉积所占胰岛面积的百分比）评估胰岛淀粉样沉积的负荷。
女性（n = 80）和男性（n = 155）的死亡年龄、糖尿病病程、体重指数和糖化血红蛋白（Hb）A1c水平相似。30.0%的女性和44.5%的男性发现有胰岛淀粉样变（P = 0.035）。9名年龄小于50岁的女性均无胰岛淀粉样变。女性受淀粉样变影响的胰岛频率为31.5%±13.1%，男性为41.1%±14.3%（P = 0.008）。女性受淀粉样变影响的胰岛面积严重程度为29.0%±12.5%，男性为38.5%±14.6%（P = 0.007）。
性别是2型糖尿病患者胰岛淀粉样变发生的一个决定因素。胰岛淀粉样变的这种性别差异可能与女性性激素的潜在益处有关。
