Wunderlich Stefan, Knochel Paul
Department Chemie and Biochemie, Ludwig-Maximilians-Universität, 81377 Munich, Germany.
Org Lett. 2008 Oct 16;10(20):4705-7. doi: 10.1021/ol802118e. Epub 2008 Sep 25.
A wide range of polyfunctional aryl and heteroaryl zinc reagents were efficiently prepared in THF via direct zincation using (tmp)2Zn x 2 MgCl2 x 2 LiCl and microwave irradiation. Ester and cyano functions as well as ketones are compatible with the high temperatures of the zincation. The resulting bis-organo zinc species undergo a number of subsequent reactions leading to highly functionalized aromatics and heteroaromatics in good to excellent yields.
通过使用(tmp)₂Zn·2MgCl₂·2LiCl并在微波辐射下于四氢呋喃中直接锌化，高效制备了多种多官能团芳基和杂芳基锌试剂。酯基、氰基官能团以及酮与锌化反应的高温条件兼容。所得的双有机锌物种会发生一系列后续反应，以良好至优异的产率生成高度官能化的芳烃和杂芳烃。
