van Leeuwen F W, vd Beek E M, van Heerikhuize J J, Sluiter A A, Felix D, Imboden H
Netherlands Institute for Brain Research, Amsterdam.
Neurosci Lett. 1991 Jun 24;127(2):207-11. doi: 10.1016/0304-3940(91)90795-u.
The homozygous Brattleboro rat (di/di) synthesizes a vasopressin (VP) precursor with a different C-terminus, which is not packaged in granules. In addition, the expression of a coexisting peptide, angiotensin II (Ang II), is disturbed. During postnatal life a small but increasing number of solitary post-mitotic hypothalamic neurons of the di/di rat undergoes a switch to a genuine heterozygous phenotype. Here we report the reappearance of Ang II in these heterozygous cells, which suggests that for the expression of Ang II a normal VP precursor is required. Based upon the present study and literature data it is proposed that at the level of the endoplasmic reticulum a compartmentalization of the synthesis of various peptide precursor occurs.
纯合的布拉特洛维大鼠（di/di）合成一种具有不同C末端的血管加压素（VP）前体，该前体不被包装在颗粒中。此外，共存肽血管紧张素II（Ang II）的表达也受到干扰。在出生后的生命过程中，di/di大鼠中一小部分但数量不断增加的有丝分裂后下丘脑孤立神经元会转变为真正的杂合表型。在此我们报告这些杂合细胞中Ang II的重新出现，这表明Ang II的表达需要正常的VP前体。基于本研究和文献数据，有人提出在内质网水平会发生各种肽前体合成的区室化。
