Zhu Qing-Tang, Zhu Jia-Kai, Chen Gary Y
Division of Microsurgery and Orthopedic Trauma, the First Affiliated Hospital at Sun Yat-Sen University, 58 Zhongsan Er Road, Guangzhou, Guangdong 510080, China.
Orthopedic Surgery Program, California Hospital Medical Center, Los Angeles, California, USA.
Muscle Nerve. 2008 Nov;38(5):1506-1509. doi: 10.1002/mus.21116.
Various studies have demonstrated collateral regeneration of the donor nerve following end-to-side neurorrhaphy, but the location of collateral sprouting remains controversial. In a rat end-to-side neurorrhaphy model we isolated nerve fibers from the donor nerve at the neurorrhaphy site utilizing a micro-tease technique. We found that axons sprouted collaterally from a myelinated nerve fiber at the node of Ranvier. Based on this preliminary result we conclude that myelinated nerve fibers could sprout collateral branches at the node of Ranvier at an end-to-side neurorrhaphy site. These findings show that end-to-side neurorrhaphy may be an alternative for peripheral nerve repair.
多项研究已证实端侧神经吻合术后供体神经的侧支再生，但侧支芽生的位置仍存在争议。在大鼠端侧神经吻合模型中，我们采用微分离技术在神经吻合部位从供体神经中分离出神经纤维。我们发现轴突从郎飞结处的有髓神经纤维发出侧支芽生。基于这一初步结果，我们得出结论，在端侧神经吻合部位，有髓神经纤维可在郎飞结处发出侧支分支。这些发现表明端侧神经吻合术可能是周围神经修复的一种替代方法。
