Beris Alexandros, Lykissas Marios, Korompilias Anastasios, Mitsionis Grigorios
Department of Orthopaedics, University of Ioannina, Ioannina, Greece.
J Neurotrauma. 2007 May;24(5):909-16. doi: 10.1089/neu.2006.0165.
In peripheral nerve injury, end-to-side neurorrhaphy has been reported as an alternative in cases that the proximal nerve stump is not accessible. Several hypotheses have been proposed to explain peripheral nerve regeneration after end-to-side neurorrhaphy. Recent evidence suggests that nerve regeneration occurs by collateral sprouting. Although a great number of humoral factors have been identified, molecular mechanism of nerve regeneration after end-to-side neurorrhaphy has not been completely clarified yet. The goal of this technique is to provide satisfactory functional recovery for the recipient nerve, without any deterioration of the donor nerve function. End-to-side technique has been investigated in detail in both experimental and clinical studies. Only a limited number of reported cases in clinical practice, until today, can reveal that end-to-side technique may become a viable means of repairing peripheral nerves in certain clinical situations.
在周围神经损伤中，对于近端神经残端无法进行处理的病例，端侧神经吻合术已被报道可作为一种替代方法。已经提出了几种假说来解释端侧神经吻合术后的周围神经再生。最近的证据表明，神经再生是通过侧支发芽发生的。尽管已经鉴定出大量的体液因子，但端侧神经吻合术后神经再生的分子机制尚未完全阐明。该技术的目标是为受区神经提供满意的功能恢复，而不会使供区神经功能出现任何恶化。端侧技术已在实验和临床研究中进行了详细研究。直到今天，临床实践中报道的病例数量有限，这表明端侧技术在某些临床情况下可能成为修复周围神经的可行方法。
