环氧合酶-1 或 -2 预先形成的亚油酸氢过氧化物对各自酶催化花生四烯酸形成前列腺素的调节作用。
Role of linoleic Acid hydroperoxide preformed by cyclooxygenase-1 or -2 on the regulation of prostaglandin formation from arachidonic Acid by the respective enzyme.
机构信息
Department of Physiological Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
出版信息
J Clin Biochem Nutr. 2008 Sep;43(2):65-8. doi: 10.3164/jcbn.2008047.
Abstract
Linoleic acid (LA) preincubated with cyclooxygenase (COX)-1 or -2 inhibited prostaglandin (PG) formation from arachidonic acid (AA) catalyzed by the respective enzyme, but LA without the preincubation did not. 13S-Hydroperoxy-9Z,11E-octadecadienoic acid (13-HPODE) a hydroperoxy adduct of LA inhibited PG formation catalyzed by COX-1 or -2. 13S-Hydroxy-9Z,11E-octadecadienoic acid had no effect on both COX-1 and -2 activities. These results suggest that 13-HPODE which is preformed from LA by COX reaction under normal physiological conditions can be a basal suppressor of PG formation from AA.
摘要
亚油酸（LA）与环氧化酶（COX）-1 或 -2 预孵育可抑制各自酶催化的花生四烯酸（AA）合成前列腺素（PG），但未经预孵育的 LA 则没有这种作用。13S-过氧-9Z，11E-十八碳二烯酸（13-HPODE）是 LA 的过氧加合物，可抑制 COX-1 或 -2 催化的 PG 合成。13S-羟基-9Z，11E-十八碳二烯酸对 COX-1 和 -2 的活性均没有影响。这些结果表明，在正常生理条件下，由 COX 反应从 LA 预先形成的 13-HPODE 可以作为 AA 生成 PG 的基础抑制剂。
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