Elewaut Dirk, Van den Bosch Filip, Verbruggen Gust, de Keyser Filip, Cruyssen Bert Vander, Mielants Herman
Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.
Rheumatol Int. 2009 Jan;29(3):239-50. doi: 10.1007/s00296-008-0714-5. Epub 2008 Sep 26.
Spondyloarthritides (SpAs) are a cluster of chronic inflammatory rheumatic diseases that typically involve inflammation of axial and peripheral joint or tendon and ligament insertions, distinct radiographic changes and diverse extra-articular features. Conventional treatments relieve the signs and symptoms but do not prevent disease progression. TNFalpha inhibitors provide clinicians with the potential to treat the underlying pathology and to alter disease progression. By targeting the underlying inflammatory mechanisms, TNFalpha blockade can treat any extra-articular manifestations of SpA.
脊柱关节炎（SpAs）是一组慢性炎症性风湿性疾病，通常累及中轴和外周关节或肌腱及韧带附着点的炎症、独特的影像学改变和多样的关节外表现。传统治疗可缓解体征和症状，但不能阻止疾病进展。肿瘤坏死因子α（TNFα）抑制剂为临床医生提供了治疗潜在病理改变并改变疾病进展的可能性。通过靶向潜在的炎症机制，TNFα阻断可治疗SpA的任何关节外表现。
