Becker Catherina G, Becker Thomas
Centre for Neuroscience Research, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK.
Restor Neurol Neurosci. 2008;26(2-3):71-80.
Adult fish, in contrast to mammals, are capable of regenerating axonal tracts as well as cells and even entire tissues in the central nervous system (CNS). The zebrafish is a powerful genetic model for studies on the developing CNS and is now emerging as a CNS regeneration model. Here we review recent progress in adult regeneration paradigms in zebrafish ranging from axonal re-growth models to those of tissue regeneration. Moreover, we review the tools that have become available in zebrafish to elucidate the factors contributing to successful CNS regeneration. Since many molecular pathways are shared between zebrafish and mammals, it is hoped that insights from zebrafish may contribute to future therapeutic approaches in CNS injury and disease.
与哺乳动物不同，成年鱼类能够再生中枢神经系统（CNS）中的轴突束、细胞甚至整个组织。斑马鱼是研究发育中的中枢神经系统的强大遗传模型，现在正成为一种中枢神经系统再生模型。在这里，我们回顾了斑马鱼成年再生模式的最新进展，从轴突再生模型到组织再生模型。此外，我们还回顾了斑马鱼中可用于阐明促成中枢神经系统成功再生的因素的工具。由于斑马鱼和哺乳动物之间共享许多分子途径，因此希望从斑马鱼中获得的见解可能有助于未来中枢神经系统损伤和疾病的治疗方法。
