Mills Paul J, Shapiro David, Goldstein Iris B, Ottaviani Cristina, Pung Meredith A, Khandrika Srikrishna, von Känel Roland, Rutledge Thomas R
Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
Obesity (Silver Spring). 2008 Dec;16(12):2702-6. doi: 10.1038/oby.2008.420. Epub 2008 Sep 25.
Elevated levels of inflammatory biomarkers are associated with the pathophysiology of cardiovascular diseases and are predictors of cardiovascular events. The objective of this study was to determine the unique contributions of metabolic factors as predictors of inflammation (C-reactive protein (CRP) and interleukin-6 (IL-6)), adhesion (soluble intercellular adhesion molecule-1 (sICAM-1)), and coagulation (D-dimer) in healthy younger-aged adults. Participants were 83 women and 92 men (mean age 30.04 years, s.d. +/- 4.8, range 22-39) of normal weight to moderate obese weight (mean BMI 24.4 kg/m(2), s.d. +/- 3.35, range 17-32). The primary data analytical approaches included Pearson correlation and multiple linear regression. Circulating levels of CRP, IL-6, sICAM-1, and D-dimer were determined in plasma. Higher levels of CRP were independently associated with higher BMI, a greater waist-to-hip ratio, female gender, and higher triglycerides (P < 0.001). Higher IL-6 levels were independently associated with a greater waist-to-hip ratio (P < 0.01). Higher levels of sICAM-1 were independently associated with higher BMI, higher triglycerides, and lower insulin resistance (P < 0.001). Higher D-dimer levels were independently associated with higher BMI and being female (P < 0.001). Having a higher BMI was most consistently associated with elevated biomarkers of inflammation, adhesion, and coagulation in this sample of healthy younger-aged adults, although female gender, insulin resistance, and lipid levels were also related to the biomarkers. The findings provide insight into the adverse cardiovascular risk associated with elevated body weight in younger adults.
炎症生物标志物水平升高与心血管疾病的病理生理学相关，并且是心血管事件的预测指标。本研究的目的是确定代谢因素作为炎症（C反应蛋白（CRP）和白细胞介素-6（IL-6））、黏附（可溶性细胞间黏附分子-1（sICAM-1））和凝血（D-二聚体）预测指标在健康年轻成年人中的独特作用。研究对象为83名女性和92名男性（平均年龄30.04岁，标准差±4.8，年龄范围22 - 39岁），体重正常至中度肥胖（平均体重指数24.4 kg/m²，标准差±3.35，范围17 - 32）。主要数据分析方法包括Pearson相关性分析和多元线性回归。测定血浆中CRP、IL-6、sICAM-1和D-二聚体的循环水平。较高的CRP水平独立地与较高的体重指数、更大的腰臀比、女性性别和较高的甘油三酯相关（P < 0.001）。较高的IL-6水平独立地与更大的腰臀比相关（P < 0.01）。较高的sICAM-1水平独立地与较高的体重指数、较高的甘油三酯和较低的胰岛素抵抗相关（P < 0.001）。较高的D-二聚体水平独立地与较高的体重指数和女性性别相关（P < 0.001）。在这个健康年轻成年人样本中，较高的体重指数最一致地与炎症、黏附和凝血生物标志物升高相关，尽管女性性别、胰岛素抵抗和血脂水平也与这些生物标志物有关。这些发现为年轻成年人中体重增加相关的不良心血管风险提供了见解。
