他汀类药物的使用与帕金森病风险：一项巢式病例对照研究。

Statin use and the risk of Parkinson disease: a nested case control study.

作者信息

Samii Ali, Carleton Bruce C, Etminan Mahyar

机构信息

Department of Neurology, University of Washington, Seattle VA Parkinson Disease Research Education and Clinical Center (PADRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, MS-127, Seattle, WA 98108, USA.

出版信息

J Clin Neurosci. 2008 Nov;15(11):1272-3. doi: 10.1016/j.jocn.2008.01.016. Epub 2008 Sep 26.

DOI:10.1016/j.jocn.2008.01.016

PMID:18823780

Abstract

Using the British Columbia Linked Health Databases, we explored the association between the use of statin drugs and the risk of developing Parkinson disease (PD). We followed a cohort of older adults in the Province of British Columbia from 1997 to 2003. Using a study design of nested case control (case-control study within a cohort), the relative risk of developing PD for statin users was 0.94 (0.82-1.09). Our study did not show a statistically significant effect on the risk of PD with statin use.

摘要

利用不列颠哥伦比亚省关联健康数据库，我们探究了他汀类药物的使用与患帕金森病（PD）风险之间的关联。我们对1997年至2003年不列颠哥伦比亚省的一组老年人进行了随访。采用巢式病例对照研究设计（队列中的病例对照研究），他汀类药物使用者患PD的相对风险为0.94（0.82 - 1.09）。我们的研究未显示出他汀类药物使用对PD风险有统计学上的显著影响。