一种昼行性富含视锥细胞的实验性啮齿动物——尼罗河草鼠（非洲沼鼠）的视网膜电图（ERG）。
The electroretinogram (ERG) of a diurnal cone-rich laboratory rodent, the Nile grass rat (Arvicanthis niloticus).
作者信息
Gilmour Gregory S, Gaillard Frédéric, Watson Juliane, Kuny Sharee, Mema Silvina C, Bonfield Stephan, Stell William K, Sauvé Yves
机构信息
Department of Ophthalmology, University of Alberta, Alta., Canada.
出版信息
Vision Res. 2008 Dec;48(27):2723-31. doi: 10.1016/j.visres.2008.09.004. Epub 2008 Oct 19.
The most widespread models to study blindness, rats and mice, have retinas containing less than 3% cones. The diurnal rodent Arvicanthis niloticus retina has around 35% cones. Using ERG recordings, we studied retina function in this species. Several features differed from that reported in rats and mice: (a) fivefold larger photopic a-wave amplitudes; (b) photopic hill effect in Nile grass rats only; and (c) flicker amplitude plateau between 5 to 35 Hz with fusion beyond 60 Hz in Nile grass rats only. We conclude that A. niloticus might complement rats and mice for studying retinal function and pathologies involving cones.
用于研究失明的最广泛使用的模型——大鼠和小鼠，其视网膜中视锥细胞含量不到3%。昼行性啮齿动物尼罗多齿小家鼠的视网膜中约有35%的视锥细胞。我们利用视网膜电图记录研究了该物种的视网膜功能。有几个特征与大鼠和小鼠的报道不同：(a) 明视a波振幅大五倍；(b) 仅尼罗草鼠存在明视峰效应；(c) 仅尼罗草鼠在5至35赫兹之间闪烁振幅平稳，且在60赫兹以上发生融合。我们得出结论，尼罗多齿小家鼠可能在研究涉及视锥细胞的视网膜功能和病理方面补充大鼠和小鼠的不足。
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