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[新鲜、经福尔马林处理及腐败尸体材料中肝脏脂肪营养不良的诊断]

[The diagnosis of fatty dystrophy of the liver in fresh, formalin-treated and putrefactive cadaveric material].

作者信息

Purdiaev Iu S, Alisievich V I

出版信息

Sud Med Ekspert. 1991 Apr-Jun;34(2):8-11.

PMID:1882415
Abstract

In the course of investigation it was stated that fat hepatic dystrophy can be diagnosed by biochemical method (lipid extraction by hexane). For al this the content of extracted lipids more than 20% of dry residue evidences about the presence of fat hepatic dystrophy which is confirmed by histological detection of lipid granules whose quantity is increasing from fat dystrophy I degree (lipid content amounts up to 30% of dry residue) to fat dystrophy III degree (lipid content is more than 40%). Formalin treatment doesn't produce significant changes in lipid content and doesn't prevent biochemical diagnosis of fat dystrophy of the liver. In case of putrefied liver lipid content is increased slightly but in all periods of putrefaction lipid content in the liver in case of fat dystrophy remains significantly higher than in controls. Biochemical method may be used in diagnosis of fat hepatic dystrophy and its degree not only on fresh and formalin-treated cadaveric material but also in case of markedly pronounced putrefactive changes when other methods are useless and this fact is of great value for medicolegal practice.

摘要

在调查过程中指出,脂肪性肝营养不良可通过生化方法(用己烷提取脂质)进行诊断。对于所有这些情况,提取的脂质含量超过干残渣的20%表明存在脂肪性肝营养不良,这通过组织学检测脂质颗粒得到证实,脂质颗粒的数量从脂肪营养不良I度(脂质含量高达干残渣的30%)到脂肪营养不良III度(脂质含量超过40%)不断增加。福尔马林处理不会使脂质含量产生显著变化,也不会妨碍对肝脏脂肪营养不良的生化诊断。在肝脏腐败的情况下,脂质含量略有增加,但在脂肪营养不良的情况下,肝脏在所有腐败阶段的脂质含量仍显著高于对照组。生化方法不仅可用于诊断新鲜和经福尔马林处理的尸体材料中的脂肪性肝营养不良及其程度,而且在其他方法无用且明显存在明显腐败变化的情况下也可使用,这一事实对法医学实践具有重要价值。

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