Ishikawa Takuya, Takeda Kinichi, Itoh Masatsugu, Imaizumi Tadashi, Oguri Kenji, Takahashi Hiroshi, Kasuga Hirotake, Toriyama Takanobu, Matsuo Seiichi, Hirooka Yoshiki, Itoh Akihiro, Kawashima Hiroki, Kasugai Toshifumi, Ohno Eizaburo, Miyahara Ryoji, Ishigami Masatoshi, Katano Yoshiaki, Ohmiya Naoki, Niwa Yasumasa, Goto Hidemi
Department of Gastroenterology, Nagoya Kyoritsu Hospital, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Pancreas. 2009 Mar;38(2):175-9. doi: 10.1097/MPA.0b013e31818786c9.
Pancreatic cystic (PC) lesions are not necessarily rare, and it is important to diagnose whether PC lesions are neoplastic such as intraductal papillary mucinous neoplasm (IPMN) because of its malignant potential. Reports on PC lesions in hemodialysis (HD) patients are remarkably limited. The aim of this study was to clarify the prevalence and characteristics of PC lesions in HD patients.
We reviewed 1012 consecutive HD patients and 11,100 patients (controls) without renal disease who underwent transabdominal ultrasonography between January 2003 and December 2005. Patients' sex ratio (female-to-male) was less, and the age was older in HD patients. Clinical findings of these patients were examined.
The prevalence both of PC lesions and IPMNs was significantly higher in HD patients than in controls (9.3% vs 1.3% and 2.8% vs 0.2%, P < 0.0001). The incidence of IPMNs in HD patients with PC lesions was higher than that in controls with PC lesions (29.8% vs 17.0%, P = 0.021). Multivariate logistic regression analysis revealed that the odds ratios of PC lesions and IPMNs were 6.38 (95% confidence interval, 4.82-8.45) and 9.39 (95% confidence interval, 5.36-16.49) in HD patients compared with controls.
The prevalence of PC lesions in HD patients is higher, and HD patients with PC lesions have high prevalence of IPMNs.
胰腺囊性（PC）病变并非罕见，由于导管内乳头状黏液性肿瘤（IPMN）具有恶性潜能，因此诊断PC病变是否为肿瘤性病变（如IPMN）很重要。关于血液透析（HD）患者PC病变的报道非常有限。本研究的目的是阐明HD患者中PC病变的患病率及特征。
我们回顾了2003年1月至2005年12月期间连续接受经腹超声检查的1012例HD患者和11100例无肾脏疾病的患者（对照组）。HD患者的性别比（女性与男性）较低，且年龄较大。对这些患者的临床检查结果进行了检查。
HD患者中PC病变和IPMN的患病率均显著高于对照组（9.3%对1.3%，2.8%对0.2%，P<0.0001）。有PC病变的HD患者中IPMN的发生率高于有PC病变的对照组（29.8%对17.0%，P = 0.021）。多因素逻辑回归分析显示，与对照组相比，HD患者中PC病变和IPMN的优势比分别为6.38（95%置信区间，4.82 - 8.45）和9.39（95%置信区间，5.36 - 16.49）。
HD患者中PC病变的患病率较高，且有PC病变的HD患者中IPMN的患病率也较高。
