Lenz Daniel, Rothschild Markus A, Kröner Lars
Institute of Legal Medicine, University of Cologne, Cologne, Germany.
Ther Drug Monit. 2008 Dec;30(6):755-61. doi: 10.1097/FTD.0b013e3181898c2e.
In Europe, the misuse of gamma-hydroxybutyric acid (GHB) and its analogues has increased within the recent years. Here, 2 fatalities and 1 nonfatal intoxication resulting from ingestion of gamma-butyrolactone (GBL), a precursor of GHB, are presented. GHB was quantified involving the conversion to GBL by application of a gas chromatography-mass spectrometry (GC/MS) method. Besides quantitation of GHB equivalents ("total GBL"), all specimens of case 1 were analyzed for the metabolic precursor GBL itself (absolute GBL). The cause of death in each case was attributed to GHB intoxication; the manner of death was suicide in the first case and accidental in the second one. Another yet nonfatal GHB intoxication was reported by an emergency department concerning a 36-year-old woman who was hospitalized due to her comatose state and loss of adverse effects reflexes. Here nail polish remover pads were used as source for GBL.
近年来，在欧洲，γ-羟基丁酸（GHB）及其类似物的滥用情况有所增加。本文介绍了2例因摄入GHB的前体γ-丁内酯（GBL）导致的死亡病例以及1例非致命性中毒病例。通过应用气相色谱-质谱联用（GC/MS）方法将GHB转化为GBL来对其进行定量。除了对GHB当量（“总GBL”）进行定量外，还对病例1的所有样本进行了代谢前体GBL本身（绝对GBL）的分析。每例的死亡原因均归因于GHB中毒；第一例的死亡方式为自杀，第二例为意外。急诊科报告了另一例非致命性GHB中毒事件，涉及一名36岁女性，她因昏迷状态和不良反应反射丧失而住院。在此事件中，指甲油去除剂垫被用作GBL的来源。
