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GHB/GBL 中毒:救护车就诊过量的特征和趋势。

Intoxication with GHB/GBL: characteristics and trends from ambulance-attended overdoses.

机构信息

The Norwegian Centre for Addiction Research, The University of Oslo, Oslo, Norway.

Bergen Emergency Medical Services, Department of Anesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway.

出版信息

Scand J Trauma Resusc Emerg Med. 2017 Sep 22;25(1):98. doi: 10.1186/s13049-017-0441-6.

Abstract

BACKGROUND

Overdoses from so-called "club drugs" (GHB/GBL) have become a more frequent cause of overdoses attended by ambulance services. Given its availability, affordability, and lack of awareness of risks, there is a common misconception among users that the drug is relatively safe.

METHODS

This study reviewed ambulance records in Bergen, Norway between 2009 and 2015 for cases of acute poisonings, particularly from suspected GHB/GBL intoxication.

RESULTS

In total, 1112 cases of GHB and GBL poisoning were identified. GHB was suspected for 995 (89%) of the patients. Men made up the majority of the cases (n = 752, 67.6%) with a median age of 27 years old. Temporal trends for GHB/GBL overdoses displayed a late-night, weekend pattern. The most frequent initial symptoms reported were unconsciousness, or reduced consciousness. Most of the patients required further treatment and transport. During the period from 2009 to 2015, there was a nearly 50% decrease in GHB/GBL overdoses from 2013 to 2014.

DISCUSSION

The characteristics of GHB/GBL overdose victims shed light on this patient group. The decrease in incidence over the years may be partly due to a legal ban on GBL in Norway, declared in 2010. It may also be due to an increase in the use of MDMA/ecstasy.

CONCLUSION

The review of ambulance records on the prehospital treatment of overdoses can be beneficial in monitoring, preparing, and prevention efforts aimed to benefit this vulnerable group.

摘要

背景

所谓的“俱乐部药物”(GHB/GBL)过量已成为救护车服务治疗的更常见原因。由于其易得性、可负担性以及对风险的认识不足,使用者普遍存在一种误解,认为该药物相对安全。

方法

本研究回顾了 2009 年至 2015 年期间挪威卑尔根的救护车记录,主要针对疑似 GHB/GBL 中毒的急性中毒病例。

结果

共发现 1112 例 GHB 和 GBL 中毒病例。995 例(89%)疑似 GHB。男性占大多数(n=752,67.6%),中位年龄为 27 岁。GHB/GBL 过量的时间趋势显示出深夜和周末的模式。报告的最初症状最常见的是失去知觉或意识降低。大多数患者需要进一步治疗和转运。在 2009 年至 2015 年期间,2013 年至 2014 年 GHB/GBL 过量的发生率下降了近 50%。

讨论

GHB/GBL 过量受害者的特征反映了这一患者群体的特点。近年来发病率的下降可能部分归因于挪威 2010 年宣布的 GBL 合法禁令,也可能是由于 MDMA/摇头丸的使用增加。

结论

对救护车记录中关于院前治疗过量的审查有助于监测、准备和预防工作,以造福这一弱势群体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85f3/5610436/ca4906471e85/13049_2017_441_Fig1_HTML.jpg

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