Yoo Eun-Gyong, Kim Duk Hee
Department of Pediatrics, College of Medicine, Pochon CHA University, Sungnam, Korea.
J Pediatr Endocrinol Metab. 2008 Aug;21(8):737-43. doi: 10.1515/jpem.2008.21.8.737.
Adiponectin is an insulin-sensitizing adipocytokine, and recently it has been suggested as a biomarker of metabolic syndrome. We studied the relationships between adiponectin and parameters of metabolic syndrome in obese children. Fasting plasma adiponectin, insulin, glucose, lipids, and anthropometric parameters were measured in 180 obese children and 125 non-obese controls. Adiponectin was significantly decreased in obese boys and girls compared to non-obese controls. Adiponectin was inversely related to body mass index, waist circumference (WC), insulin, homeostasis model assessment for insulin resistance, and triglycerides, after adjusting for age in both genders. Adiponectin was correlated with high-density lipoprotein cholesterol (HDL-C) after adjusting for age in both genders. In multiple regression analysis, WC was independently related to adiponectin in boys, and WC and HDL-C were independently related to adiponectin in girls. In conclusion, WC, a simple measure of central adiposity, is a determinant of adiponectin in obese children.
脂联素是一种具有胰岛素增敏作用的脂肪细胞因子，最近它被认为是代谢综合征的一个生物标志物。我们研究了肥胖儿童中脂联素与代谢综合征各项参数之间的关系。对180名肥胖儿童和125名非肥胖对照者测量了空腹血浆脂联素、胰岛素、葡萄糖、血脂及人体测量学参数。与非肥胖对照者相比，肥胖男孩和女孩的脂联素水平显著降低。在对两性年龄进行校正后，脂联素与体重指数、腰围（WC）、胰岛素、胰岛素抵抗稳态模型评估及甘油三酯呈负相关。在对两性年龄进行校正后，脂联素与高密度脂蛋白胆固醇（HDL-C）相关。在多元回归分析中，WC在男孩中与脂联素独立相关，而在女孩中WC和HDL-C与脂联素独立相关。总之，WC作为一种衡量中心性肥胖的简单指标, 是肥胖儿童脂联素水平的一个决定因素。
