Liu Yong-Zhi, Cao Ke-Li, Wang Yi, Wei Chao-Gang, Yang Li-Jun
Department of Otorhinolaryngology, Peking Union Medical College Hospital, Beijing 100730, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Jun;43(6):409-13.
To approach the incidence rate, symptoms, etiologies, correlating reasons, consequences and treatments of local responses caused by implant after cochlear implantation and to provide reference for the future works.
From 1995 to 2007 there were 997 cases adopted cochlear implantation in Peding Union Medical College Hospital. Ten cases experienced local responses were analyzed retrospectively.
The incidence of local response was 1.003%. There were 6 males and 4 females. The ages were between 13 months to 8 years old. The average age was 34 months. The devices mainly were made by Cochlear and Med-EL companies. The mainly symptoms and signs were local swellings, complaint of pruritus after ear, decrease of sound legibility and so on. Onset frequencies of this disease was 1 to 8 times. The bacterium cultured of displacing liquids was negative. But the IgE was detected in 2 cases. Results showed the patients were midrange status of hypersensitivity. Positive conservative treatments must be done including antibiotics, antihistamines, necessarily using immunotherapy.
Besides local infection of bacteria, the allergy caused by silicone of implant coupled be a reason. Although the diagnose of this disease was difficult, but the screening of source of hypersensitivity was necessary before operation. It was recurrent attacks and maybe liable by kindred patients. Onset age was more below 4 years old. The patch test should be done again when the symptoms were occurrence after operation. If severe secondary infection was occurred and the states could not be well controlled the devices in the body must be explanted immediately. When the conditions were stable reimplantation could be experienced by non-sensibilisinogen devices.
探讨人工耳蜗植入术后局部反应的发生率、症状、病因、相关因素、后果及治疗方法,为今后的工作提供参考。
1995年至2007年,北京协和医院共997例患者接受人工耳蜗植入。对10例发生局部反应的患者进行回顾性分析。
局部反应发生率为1.003%。男性6例,女性4例。年龄在13个月至8岁之间,平均年龄34个月。所用装置主要来自科利耳公司和梅德-埃尔公司。主要症状和体征为局部肿胀、耳部瘙痒、声音清晰度下降等。发病次数为1至8次。引流液细菌培养阴性,但2例检测到IgE。结果显示患者为中度过敏状态。必须进行积极的保守治疗,包括使用抗生素、抗组胺药,必要时采用免疫疗法。
除局部细菌感染外,植入物硅胶引起的过敏可能是一个原因。本病诊断虽难,但术前需筛查过敏源。本病易反复发作,可能有家族易感性。发病年龄多在4岁以下。术后出现症状时应再次进行斑贴试验。若发生严重继发感染且病情无法良好控制,必须立即取出体内装置。病情稳定后可使用非致敏原装置再次植入。