Gilmore C P, Donaldson I, Bö L, Owens T, Lowe J, Evangelou N
Department of Neurology, B Floor Medical School, Queen's Medical Centre NHS Trust, Nottingham NG7 2UH, UK.
J Neurol Neurosurg Psychiatry. 2009 Feb;80(2):182-7. doi: 10.1136/jnnp.2008.148767. Epub 2008 Oct 1.
Substantial grey matter (GM) demyelination occurs in both the cerebral cortex and spinal cord in multiple sclerosis (MS). GM demyelination also occurs in the cerebellar cortex and the deep GM nuclei of the brain. However, no study has made a direct "within subject" comparison of the extent of GM pathology between these regions.
To examine the extent and pattern of GM demyelination in the motor cortex, cingulate gyrus, cerebellum, thalamus and spinal cord in MS.
Postmortem study using material from 14 MS cases and three controls. Sections were taken from the five predetermined areas and stained for proteolipid protein. The extent of GM and white matter (WM) demyelination was assessed in each region.
Overall, 28.8% of the GM was demyelinated compared with 15.6% of the WM (p<0.001), with demyelination being greater in the GM than in the WM at each of the anatomical sites. There was substantial variation in the extent of demyelination between the different CNS regions. GM demyelination was most extensive in the spinal cord and cerebellum while WM demyelination was most prominent in the spinal cord.
在多发性硬化症（MS）中，大脑皮层和脊髓均会出现大量灰质（GM）脱髓鞘。小脑皮层和脑深部灰质核团也会发生GM脱髓鞘。然而，尚无研究对这些区域之间GM病变程度进行直接的“受试者内”比较。
研究MS患者运动皮层、扣带回、小脑、丘脑和脊髓中GM脱髓鞘的程度和模式。
采用14例MS病例和3例对照的尸检材料进行研究。从五个预定区域取材切片，并进行蛋白脂质蛋白染色。评估每个区域GM和白质（WM）脱髓鞘的程度。
总体而言，GM脱髓鞘比例为28.8%，而WM为15.6%（p<0.001），在每个解剖部位，GM的脱髓鞘程度均高于WM。不同中枢神经系统区域的脱髓鞘程度存在显著差异。GM脱髓鞘在脊髓和小脑中最为广泛，而WM脱髓鞘在脊髓中最为明显。
