Department of Pharmaceutical Sciences, State University of New York, Buffalo, NY 14214, USA.
LabCorp Diagnostics, Morrisville, NC 27560, USA.
Nutrients. 2024 Aug 27;16(17):2866. doi: 10.3390/nu16172866.
Metabolic vulnerabilities can exacerbate inflammatory injury and inhibit repair in multiple sclerosis (MS). The purpose was to evaluate whether blood biomarkers of inflammatory and metabolic vulnerability are associated with MS disability and neurodegeneration.
Proton nuclear magnetic resonance spectra were obtained from serum samples from 153 healthy controls, 187 relapsing-remitting, and 91 progressive MS patients. The spectra were analyzed to obtain concentrations of lipoprotein sub-classes, glycated acute-phase proteins, and small-molecule metabolites, including leucine, valine, isoleucine, alanine, and citrate. Composite indices for inflammatory vulnerability, metabolic malnutrition, and metabolic vulnerability were computed. MS disability was measured on the Expanded Disability Status Scale. MRI measures of lesions and whole-brain and tissue-specific volumes were acquired.
Valine, leucine, isoleucine, alanine, the Inflammatory Vulnerability Index, the Metabolic Malnutrition Index, and the Metabolic Vulnerability Index differed between healthy control and MS groups in regression analyses adjusted for age, sex, and body mass index. The Expanded Disability Status Scale was associated with small HDL particle levels, inflammatory vulnerability, and metabolic vulnerability. Timed ambulation was associated with inflammatory vulnerability and metabolic vulnerability. Greater metabolic vulnerability and inflammatory vulnerability were associated with lower gray matter, deep gray matter volumes, and greater lateral ventricle volume.
Serum-biomarker-derived indices of inflammatory and metabolic vulnerability are associated with disability and neurodegeneration in MS.
代谢脆弱性可能会加剧多发性硬化症（MS）中的炎症损伤并抑制修复。本研究旨在评估炎症和代谢脆弱性的血液生物标志物是否与 MS 残疾和神经退行性变有关。
从 153 名健康对照者、187 名复发缓解型和 91 名进展型 MS 患者的血清样本中获得质子磁共振波谱。对光谱进行分析，以获得脂蛋白亚类、糖化急性期蛋白和包括亮氨酸、缬氨酸、异亮氨酸、丙氨酸和柠檬酸在内的小分子代谢物的浓度。计算炎症脆弱性、代谢营养不良和代谢脆弱性的综合指数。采用扩展残疾状况量表（EDSS）评估 MS 残疾。获取 MRI 病变和全脑及组织特异性容积的测量值。
在回归分析中，经年龄、性别和体重指数调整后，亮氨酸、缬氨酸、异亮氨酸、丙氨酸、炎症脆弱性指数、代谢营养不良指数和代谢脆弱性指数在健康对照组和 MS 组之间存在差异。EDSS 与小 HDL 颗粒水平、炎症脆弱性和代谢脆弱性有关。定时行走能力与炎症脆弱性和代谢脆弱性有关。代谢脆弱性和炎症脆弱性越高，灰质、深部灰质体积越低，侧脑室体积越大。
血清生物标志物衍生的炎症和代谢脆弱性指数与 MS 中的残疾和神经退行性变有关。
