水疱性口炎病毒群体中适应性与临界瓶颈大小对数之间的线性关系。
A linear relationship between fitness and the logarithm of the critical bottleneck size in vesicular stomatitis virus populations.
作者信息
Novella Isabel S, Dutta Ranendra N, Wilke Claus O
机构信息
Department of Microbiology and Immunology, University of Toledo Health Science Campus, Mail stop 1210, Toledo, OH 43614, USA.
出版信息
J Virol. 2008 Dec;82(24):12589-90. doi: 10.1128/JVI.01394-08. Epub 2008 Oct 1.
We explored the relationship between fitness change and population size during transmission in vesicular stomatitis populations of very high fitness. The results show a linear correlation between the logarithm of the critical bottleneck size (population size at which there are no significant fitness changes after 20 passages) and the initial fitness of the population. In addition, limits to fitness increases during large-population passages of very-high-fitness strains were abolished by increasing the population size during transmission, indicating that beneficial variation is still available in these populations.
我们研究了高适应性水泡性口炎病毒群体在传播过程中适应性变化与群体大小之间的关系。结果表明，临界瓶颈大小（经过20代传代后适应性无显著变化的群体大小）的对数与群体的初始适应性之间存在线性相关性。此外，通过在传播过程中增加群体大小，消除了高适应性毒株在大群体传代过程中适应性增加的限制，这表明这些群体中仍存在有益变异。
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