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促肾上腺皮质激素对大鼠骨骼肌、脑、肝、肾及心肌切片氧摄取的影响。

The effect of ACTH on oxygen uptake by skeletal muscle, brain, liver, kidney and myocardium slices of the rat.

作者信息

Urban I

出版信息

Acta Physiol Pol. 1976 Sep-Oct;27(5):471-6.

PMID:188305
Abstract

Using Wartburg's method the effect of ACTH on oxygen uptake by slices of various tissues of the rat was investigated in relation to the duration of ACTH action in the organism. A reduction in oxygen uptake by tissue slices was found 1 hour after ACTH injection with a rise after 16 hours. It seems that in the first phase ACTH exerts an inhibitory effect on tissue respiration indirectly through the adrenal cortex, while in the second phase it may exert a stimulatory influence either directly or by some other mechanisms.

摘要

采用瓦尔特堡方法,研究了促肾上腺皮质激素(ACTH)对大鼠各种组织切片氧摄取的影响,并与ACTH在机体中的作用持续时间相关联。注射ACTH 1小时后发现组织切片的氧摄取减少,16小时后增加。似乎在第一阶段,ACTH通过肾上腺皮质间接对组织呼吸发挥抑制作用,而在第二阶段,它可能直接或通过其他一些机制发挥刺激作用。

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