Ishii H, Kanzaki Y, Hatase O, Oda T
Acta Med Okayama. 1976 Aug;30(4):221-5.
Changes in the activities of three enzymes involved in nucleotide metabolism were studied following infection of Vero cells with SV40. The results showed that SV40 infection enhanced the activities of uridine phosphokinase and UMP phosphokinase involved in nucleotide synthesis and suppressed the activity of nucleoside triphosphatases involved in nulceotide degradation. These SV40-induced enzyme activity changes probably served to somehow increase the quantity of nucleotides for virus proliferation.
在用SV40感染Vero细胞后，研究了参与核苷酸代谢的三种酶的活性变化。结果表明，SV40感染增强了参与核苷酸合成的尿苷磷酸激酶和UMP磷酸激酶的活性，并抑制了参与核苷酸降解的核苷三磷酸酶的活性。这些SV40诱导的酶活性变化可能在某种程度上有助于增加用于病毒增殖的核苷酸数量。
