Lolova I
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Anat Anz. 1991;172(4):263-71.
Ultrastructure of the glial cells in the CA 1 hippocampal field and some quantitative parameters characterizing the astrocytes in stratum lacunosum-moleculare (str. L-M) of the CA 1 hippocampal field of young-mature (3-month old) and aged (24-month old) rats were examined. The qualitative observations showed structural changes in astrocytes, oligodendrocytes and microglial cells in all layers of the CA1 hippocampal field in aged rats. The quantitative analysis demonstrated a considerable increase in total and individual volume fractions of astrocyte processes, in number of astrocyte profiles per square area of neuropil and in percentage area of neuropil occupied by astrocyte process profiles. These changes as well as the increased number of astrocyte nuclei suggest the appearance of hypertrophy and hyperplasie of astrocytes in str. L-M of the CA 1 hippocampal field of rats in aging.
研究了年轻成熟（3个月大）和老年（24个月大）大鼠海马CA1区神经胶质细胞的超微结构，以及表征海马CA1区腔隙-分子层（L-M层）星形胶质细胞的一些定量参数。定性观察显示，老年大鼠海马CA1区各层的星形胶质细胞、少突胶质细胞和小胶质细胞均有结构变化。定量分析表明，星形胶质细胞突起的总体积分数和个体积分数、每平方神经毡面积的星形胶质细胞轮廓数量以及星形胶质细胞突起轮廓所占神经毡面积的百分比均显著增加。这些变化以及星形胶质细胞核数量的增加表明，衰老大鼠海马CA1区L-M层星形胶质细胞出现肥大和增生。
