Lolova I
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Acta Morphol Hung. 1989;37(1-2):3-10.
Age-related changes in dendritic branches in stratum lacunosum-moleculare of the CA1 hippocampal field were examined using quantitative ultrastructural methods. A decrease by 38% was demonstrated in the number of dendritic branch profiles per tissue square area in the group of aged (24-month-old) rats as compared to that in the group of young adult (3-month-old) rats. The total volume fraction and total surface of dendrites per volume neuropil were decreased by 23% and 35%, respectively in aged rats. The percentage area of neuropil occupied by dendritic branch profiles was smaller in aged rats (by 22%) than that in young adult rats. The width of the layers including the apical dendrites of the CA1 hippocampal pyramidal cells was unchanged in the group of aged rats. The degree of the changes in different parameters examined suggests that the atrophy and loss of dendrites in aging hippocampus affect preferentially terminal branches.
运用定量超微结构方法研究了CA1海马区分子层中空隙层树突分支的年龄相关变化。与年轻成年（3个月大）大鼠组相比，老年（24个月大）大鼠组每组织平方区域的树突分支轮廓数量减少了38%。老年大鼠每体积神经毡中树突的总体积分数和总表面积分别减少了23%和35%。老年大鼠中树突分支轮廓占据的神经毡百分比面积比年轻成年大鼠小（22%）。老年大鼠组中包括CA1海马锥体细胞顶树突的层宽度没有变化。所检测的不同参数的变化程度表明，衰老海马体中树突的萎缩和丢失主要影响终末分支。
