Shumway N E
Stanford University, School of Medicine, California 94305.
Ann Acad Med Singap. 1991 Mar;20(2):283-6.
After ten years of experimental background, the first heart transplant at Stanford was performed on January 6, 1968. Six hundred and sixty-six patients have undergone 721 heart transplants since that date with an age range from five days to 64 years. The most common diagnosis has been cardiomyopathy with advanced coronary artery disease second. Current one and five year survival statistics are 81% and 60% respectively, with no difference in survival between the pediatric age group and adults. Percutaneous transvenous endomyocardial biopsy provides the gold standard for interpreting allograft rejection. At Stanford, 90 patients have undergone 91 heart-lung transplants since the first successful case in 1981. Twelve patients with cystic fibrosis have been transplanted and four of these recipients have been heart donors, the domino donor principle. Two double lung transplants have been performed utilising separate bronchial anastomoses. Fourteen patients have undergone 15 single lung transplants and three of these have been patients with the Eisenmenger syndrome where concomitant repair of the cardiac defect was carried out. One 12 year old patient received the right upper lobe of her mother as a total right lung transplant for bronchopulmonary dysplasia.
在经过十年的实验背景积累后，斯坦福大学于1968年1月6日进行了首例心脏移植手术。自那时起，666名患者接受了721次心脏移植，年龄范围从5天至64岁。最常见的诊断是心肌病，其次是晚期冠状动脉疾病。目前的一年和五年生存率统计分别为81%和60%，儿童年龄组和成人的生存率没有差异。经皮经静脉心内膜活检是解释同种异体移植排斥反应的金标准。在斯坦福大学，自1981年首例成功病例以来，90名患者接受了91次心肺移植。12名囊性纤维化患者接受了移植，其中4名受者成为心脏供体，即多米诺供体原则。利用单独的支气管吻合术进行了2例双肺移植。14名患者接受了15次单肺移植，其中3例是艾森曼格综合征患者，同时进行了心脏缺陷修复。一名12岁的患者接受了其母亲的右上叶作为全右肺移植，用于治疗支气管肺发育不良。
