Papakonstantinou P, Tziris N, Kesisoglou I, Gotzamani-Psarrakou A, Tsonidis Chr, Patsikas M N, Papazoglou L G
Aristotle University of Thessaloniki, AHEPA University Hospital, 3rd Surgical Clinic, Greece.
Int J Immunopathol Pharmacol. 2008 Jul-Sep;21(3):527-38. doi: 10.1177/039463200802100306.
In 1998, Orexin A was added to the long list of orexigenic neuropeptides of the brain's physiology. Orexin A is involved in the central control of appetite and in energy homeostasis, as well as in the regulation of many other physiological functions. It is produced by a small cluster of the brain's neurons, located mainly in and around the lateral hypothalamic area. This site is known to be involved in regulating feeding in mammals. An intracerebroventricular injection of Orexin A into the rat's brain causes an impressive increase in the consumption of food, while an intravenous injection induces changes on glucagon plasma concentrations in rats. In addition, there are signs of changes on glucagon plasma concentrations when Orexin A acts on individual pancreatic islets of rats. In this study, we investigated the potential effects of the central administration of porcine Orexin A on glucagon plasma concentrations in pigs, and examined whether these changes are associated with the possible effect of the neuropeptide on the enteroinsular axis.
1998年，食欲素A被添加到大脑生理学中促食欲神经肽的长长的名单中。食欲素A参与食欲的中枢控制和能量稳态，以及许多其他生理功能的调节。它由一小群大脑神经元产生，主要位于下丘脑外侧区及其周围。已知该部位参与调节哺乳动物的进食。向大鼠脑室内注射食欲素A会导致食物消耗量显著增加，而静脉注射则会引起大鼠血浆胰高血糖素浓度的变化。此外，当食欲素A作用于大鼠的单个胰岛时，也有血浆胰高血糖素浓度变化的迹象。在本研究中，我们研究了向猪中枢给予猪食欲素A对猪血浆胰高血糖素浓度的潜在影响，并检查了这些变化是否与该神经肽对肠胰岛轴的可能作用有关。
