Sparatore B, Patrone M, Passalacqua M, Melloni E, Pontremoli S
Institute of Biological Chemistry, University of Genoa, Italy.
Biochem Biophys Res Commun. 1991 Aug 30;179(1):153-60. doi: 10.1016/0006-291x(91)91348-g.
A protein factor previously shown to enhance terminal differentiation of transformed erythroid cells is synthesized by murine erythroleukemia cells and secreted in the early stages of differentiation induced by hexamethylenebisacetamide (HMBA). Secretion also occurs, constitutively, in the absence of inducer, from a murine erythroleukemia cell variant characterized by an accelerated response to HMBA. The protein factor binds to intact cells following addition of HMBA and enhances translocation of protein kinase C to the nuclear fraction. These results strongly support an important role for this natural protein factor in cell differentiation.
一种先前已被证明可增强转化红细胞系细胞终末分化的蛋白质因子，由小鼠红白血病细胞合成，并在六亚甲基双乙酰胺（HMBA）诱导的分化早期分泌。在没有诱导剂的情况下，从一个对HMBA反应加速的小鼠红白血病细胞变体中也会持续发生分泌。添加HMBA后，该蛋白质因子与完整细胞结合，并增强蛋白激酶C向核部分的转位。这些结果有力地支持了这种天然蛋白质因子在细胞分化中起重要作用。
