DRD2基因957C>T多态性与退伍军人创伤后应激障碍有关。
The DRD2 gene 957C>T polymorphism is associated with posttraumatic stress disorder in war veterans.
作者信息
Voisey Joanne, Swagell Christopher D, Hughes Ian P, Morris C Phillip, van Daal Angela, Noble Earnest P, Kann Burnett, Heslop Karen A, Young Ross McD, Lawford Bruce R
机构信息
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
出版信息
Depress Anxiety. 2009;26(1):28-33. doi: 10.1002/da.20517.
BACKGROUND
Variations in genes related to the dopaminergic pathway have been implicated in neuropsychiatric disorders such as schizophrenia, substance misuse, Alzheimer's disease and Post Traumatic Stress Disorder (PTSD). A single nucleotide polymorphism (SNP) (957C>T) and a deletion polymorphism (-141delC) in the DRD2 gene and a SNP (Taq1A) in a gene directly downstream of DRD2 have all been implicated in dopamine functioning in the brain.
METHODS
To test the importance of these three polymorphisms in PTSD susceptibility, a genetic screen was performed in 127 war veterans diagnosed with PTSD and 228 control individuals without a history of PTSD.
RESULTS
No significant association was found between PTSD and the Taq1A or -141delC polymorphisms. However, a significant association was observed with PTSD and the 957C>T polymorphism. PTSD individuals were more likely to carry the C allele compared to the controls (P=0.021).
CONCLUSIONS
Our findings suggest that the 957C>T polymorphism in the DRD2 gene is one of the genetic factors for susceptibility to PTSD.
背景
与多巴胺能通路相关的基因变异与精神疾病有关，如精神分裂症、药物滥用、阿尔茨海默病和创伤后应激障碍（PTSD）。DRD2基因中的单核苷酸多态性（SNP）（957C>T）和缺失多态性（-141delC）以及DRD2基因下游直接相连的一个基因中的SNP（Taq1A）均与大脑中的多巴胺功能有关。
方法
为了测试这三种多态性在PTSD易感性中的重要性，对127名被诊断为PTSD的退伍军人和228名无PTSD病史的对照个体进行了基因筛查。
结果
未发现PTSD与Taq1A或-141delC多态性之间存在显著关联。然而，观察到PTSD与957C>T多态性之间存在显著关联。与对照组相比，PTSD个体更有可能携带C等位基因（P=0.021）。
结论
我们的研究结果表明，DRD2基因中的957C>T多态性是PTSD易感性的遗传因素之一。
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