Department of Epidemiology, David Gethen School of Medicine, University of California, Los Angeles, California 90073, USA.
Psychiatry Res. 2010 Aug 15;178(3):507-10. doi: 10.1016/j.psychres.2010.04.043.
The objective of this study was to assess the generality of the association of DRD2 and DAT genes and Post-Traumatic Stress Disorder (PTSD) diagnosis/symptom severity. Two hundred ethnic Armenians from 12 multigenerational families exposed to the catastrophic 1988 Spitak earthquake were studied. Common polymorphisms A1/A2 alleles of the DRD2 and '9' repeat allele of DAT gene were genotyped. Heritability, association and linkage were assessed using variance component genetic analyses. After adjusting for the covariates, the heritabilities of PTSD diagnosis and B and C category symptoms were: 0.37, 0.75 and 0.39 respectively. Category D symptoms were not heritable. Neither the DRD2 nor the DAT polymorphisms explained the variation seen in PTSD diagnosis, total PTSD symptom severity, and categories B and C symptom severities. These findings contradict prior reports of positive associations between both DRD2 and DAT, and PTSD.
这项研究的目的是评估 DRD2 和 DAT 基因与创伤后应激障碍（PTSD）诊断/症状严重程度之间关联的普遍性。研究了 12 个多代家庭的 200 名亚美尼亚族成员，他们经历了 1988 年斯皮塔克地震这一灾难性事件。对 DRD2 的 A1/A2 等位基因和 DAT 基因的“9”重复等位基因进行了常见多态性基因分型。使用方差分量遗传分析评估了遗传性、关联性和连锁性。在调整协变量后，PTSD 诊断和 B 和 C 类症状的遗传性分别为：0.37、0.75 和 0.39。D 类症状没有遗传性。DRD2 和 DAT 多态性均不能解释 PTSD 诊断、总 PTSD 症状严重程度以及 B 和 C 类症状严重程度的变化。这些发现与先前关于 DRD2 和 DAT 与 PTSD 之间存在正相关的报告相矛盾。
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