Prinetti Alessandro, Loberto Nicoletta, Chigorno Vanna, Sonnino Sandro
Center of Excellence on Neurodegenerative Diseases, Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, Segrate, Italy.
Biochim Biophys Acta. 2009 Jan;1788(1):184-93. doi: 10.1016/j.bbamem.2008.09.001. Epub 2008 Sep 12.
Glycosphingolipids, due to their tendency to form laterally separated liquid-ordered phases, possess a high potential for the creation of order in biological membranes. The formation of glycosphingolipid-rich domains within the membrane has profound consequences on the membrane organization at different levels, and on the conformational and biological properties of membrane-associated proteins and multimolecular protein complexes. In this review, we will discuss 1) how glycosphingolipids influence the lateral organization of biological membranes; 2) how glycosphingolipids influence the function of membrane-associated proteins.
糖鞘脂由于其倾向于形成侧向分离的液晶有序相，在生物膜中具有创造有序结构的巨大潜力。膜内富含糖鞘脂的结构域的形成对不同水平的膜组织以及膜相关蛋白和多分子蛋白复合物的构象和生物学特性具有深远影响。在本综述中，我们将讨论：1）糖鞘脂如何影响生物膜的侧向组织；2）糖鞘脂如何影响膜相关蛋白的功能。
