Moser M
Universität Freiburg, Innere Medizin III, Hugstetter Strasse 55, Freiburg.
Hamostaseologie. 2008 Oct;28(4):189-94.
The formation of vasculature is a key step during embryogenesis. The vasculature and the intravascular blood compartment, which uses the former as a means of transportation, develop in a close spatial and temporal relationship. This review discusses the role of the blood coagulation system, particularly thrombin, as a tool to coordinate blood vessel formation. Mouse models indicate that a lack of coagulation factors results in impaired thrombin generation and consequently display a phenotype of disturbed cardiovascular development. Similar phenotypes are present in mouse models of impaired thrombin binding to its cellular receptor PAR1 or of disrupted signaling via G-proteins. Moreover, there is compelling evidence that thrombin signaling in vascular development cannot be explained by a model based only on the classical extrinsic and intrinsic coagulation pathways. As angiogenesis in adults follows the same signaling patterns as in embryos, it is of importance to learn about these pathways, hoping that they may serve as therapeutic targets in cardiovascular disease.
血管形成是胚胎发育过程中的关键步骤。脉管系统和血管内血液腔室以脉管系统作为运输方式，二者在空间和时间上紧密相关地发育。本综述讨论了血液凝固系统，特别是凝血酶，作为协调血管形成的工具所起的作用。小鼠模型表明，凝血因子的缺乏会导致凝血酶生成受损，进而表现出心血管发育紊乱的表型。在凝血酶与其细胞受体PAR1结合受损或通过G蛋白的信号传导中断的小鼠模型中也存在类似的表型。此外，有确凿证据表明，血管发育中的凝血酶信号传导不能仅用基于经典外源性和内源性凝血途径的模型来解释。由于成体中的血管生成遵循与胚胎相同的信号模式，了解这些途径很重要，希望它们可作为心血管疾病的治疗靶点。
