McCune W J, Bayliss G E
University of Michigan Medical Center, Ann Arbor.
Curr Opin Rheumatol. 1991 Jun;3(3):355-62. doi: 10.1097/00002281-199106000-00005.
The use and complications of intravenous cyclophosphamide, azathioprine, nitrogen mustard, and cyclosporine are reviewed. Studies have failed to demonstrate superiority of intravenous versus oral cyclophosphamide in rheumatic diseases other than systemic lupus. Azathioprine is a useful immunosuppressive agent in Beçhet's disease. Further studies of cyclosporine in rheumatoid arthritis indicate that efficacy and toxicity are both dose related.
本文综述了静脉注射环磷酰胺、硫唑嘌呤、氮芥和环孢素的使用及并发症。研究未能证实在除系统性红斑狼疮外的风湿性疾病中，静脉注射环磷酰胺比口服环磷酰胺更具优势。硫唑嘌呤在白塞病中是一种有效的免疫抑制剂。对类风湿关节炎中环孢素的进一步研究表明，其疗效和毒性均与剂量相关。
