Gatto Antonino, Sebastiani Simone, Falvo Laura, Giustiniani Cristina, La Rovere Claudio
Department of Surgery, Monterotondo Hospital, Rome.
Chir Ital. 2008 Jul-Aug;60(4):577-82.
Marjolin's ulcer is an epidermoid carcinoma arising in a scar or chronic wound and is characterised by an aggressive course. We present a clinical case of ulcerated skin carcinoma of the breast arising in an 80-year-old woman, who at history taking reported a burn occurring 30 years earlier on the breast skin, with subsequent chronic ulcerative scar formation. The definitive histological examination identified a "squamous-cell carcinoma of the breast skin". We have assessed this case and reviewed the literature on Marjolin's ulcer. The patient presented a metastatic relapse of local disease after aggressive surgical treatment. In the clinical history of patients with chronic ulcers it is important to analyse the morphological changes with biopsies and subsequently with the most appropriate diagnostic techniques for the purposes of early initiation of a therapeutic program, since, in the advanced stages, even an aggressive surgical treatment may prove inadequate.
马乔林溃疡是一种发生于瘢痕或慢性伤口的表皮样癌，其特点是病程侵袭性强。我们报告一例80岁女性发生的乳腺溃疡性皮肤癌临床病例，该患者在病史采集时称30年前乳房皮肤曾发生烧伤，随后形成慢性溃疡性瘢痕。最终组织学检查确诊为“乳房皮肤鳞状细胞癌”。我们对该病例进行了评估并复习了关于马乔林溃疡的文献。该患者在积极手术治疗后出现了局部疾病的转移性复发。在慢性溃疡患者的临床病史中，重要的是通过活检及随后采用最合适的诊断技术分析形态学变化，以便早期启动治疗方案，因为在疾病晚期，即使积极的手术治疗也可能不足。
