Mendelson John, Flower Keith, Pletcher Mark J, Galloway Gantt P
California Pacific Medical Center Research Institute, St. Luke's Hospital, and Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94110, USA.
Exp Clin Psychopharmacol. 2008 Oct;16(5):435-41. doi: 10.1037/a0013637.
Dependence on and abuse of prescription opioid drugs is now a major health problem, with initiation of prescription opioid abuse exceeding cocaine in young people. Coincident with the emergence of abuse and dependence on prescription opioids, there has been an increased emphasis on the treatment of pain. Pain is now the "5th vital sign" and physicians face disciplinary action for failure to adequately relieve pain. Thus, physicians are whipsawed between the imperative to treat pain with opioids and the fear of producing addiction in some patients. In this article, the authors characterize the emerging epidemic of prescription opioid abuse, discuss the utility of buprenorphine in the treatment of addiction to prescription opioids, and present illustrative case histories of successful treatment with buprenorphine.
对处方阿片类药物的依赖和滥用如今已成为一个重大的健康问题，在年轻人中，处方阿片类药物滥用的起始人数超过了可卡因。与处方阿片类药物滥用和依赖现象的出现同时发生的是，人们越来越重视疼痛的治疗。疼痛如今是“第五生命体征”，医生若未能充分缓解疼痛将面临纪律处分。因此，医生们在必须使用阿片类药物治疗疼痛与担心某些患者会成瘾之间左右为难。在本文中，作者描述了处方阿片类药物滥用这一新兴的流行趋势，讨论了丁丙诺啡在治疗处方阿片类药物成瘾方面的效用，并列举了丁丙诺啡成功治疗的病例史。
