Turan Tanya N, Chimowitz Marc I
Department of Neurosciences, Division of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Rev Neurol Dis. 2008 Summer;5(3):117-24.
Atherosclerotic stenosis of the major intracranial arteries is an important cause of ischemic stroke. Antiplatelet agents and aggressive management of atherosclerotic risk factors, including hypertension, should play a central role in the prevention of vascular events in patients with intracranial arterial stenosis. Angioplasty and stenting are also among current therapeutic options. A randomized controlled trial of intracranial stenting plus aggressive medical therapy versus aggressive medical therapy alone is needed to determine the optimal treatment for patients with severe symptomatic intracranial stenosis.
主要颅内动脉的动脉粥样硬化性狭窄是缺血性卒中的重要病因。抗血小板药物以及对包括高血压在内的动脉粥样硬化危险因素进行积极管理，应在预防颅内动脉狭窄患者发生血管事件中发挥核心作用。血管成形术和支架置入术也是当前的治疗选择之一。需要进行一项随机对照试验，比较颅内支架置入术联合积极药物治疗与单纯积极药物治疗，以确定重度症状性颅内狭窄患者的最佳治疗方案。
