Department of Neurological Sciences, Radiology and Neurosurgery, Rush University Medical Center, Chicago, IL 60612, USA.
J Neuroimaging. 2011 Apr;21(2):e109-13. doi: 10.1111/j.1552-6569.2009.00425.x.
Quantitative magnetic resonance angiography (QMRA) is a noninvasive imaging modality that provides anatomic and physiologic measurements of arteries. We used QMRA to assess hemodynamic changes following Wingspan stent placement for intracranial stenosis.
We reviewed patients treated with Wingspan stents for intracranial stenosis who had baseline and follow-up QMRA data. We compared volumetric flow rates (VFRs) (mL/minute) pre- and poststenting using paired t-tests. P<.05 was considered significant.
Among 9 patients (mean age 65.8 years, mean 71% degree of stenosis), lesions were located in the supraclinoid internal carotid arteries in 3, middle cerebral arteries in 3, and intracranial vertebrobasilar arteries in 3. VFR and degree of stenosis were moderately correlated (r=-.670, P=.002). The mean VFR in the stenotic artery increased from 81.2 mL/minute to 133.3 mL/minute (P=.020) or by 64.2% after stenting. Total cerebral blood flow, flow in nonstented vessels, and collateral flow in circle of Willis vessels did not significantly change.
We found that QMRA is a promising noninvasive method for the measurement of cerebral hemodynamics following intracranial Wingspan stent placement. Larger prospective studies are needed to confirm our findings.
定量磁共振血管造影（QMRA）是一种非侵入性成像方式，可提供动脉的解剖学和生理学测量。我们使用 QMRA 来评估颅内狭窄后 Wingspan 支架置入后的血流动力学变化。
我们回顾了接受 Wingspan 支架治疗颅内狭窄且具有基线和随访 QMRA 数据的患者。我们使用配对 t 检验比较支架置入前后的容积血流率（VFR）（毫升/分钟）。<.05 被认为具有统计学意义。
在 9 名患者（平均年龄 65.8 岁，平均狭窄程度 71%）中，病变位于颈内动脉虹吸段 3 例、大脑中动脉 3 例、颅内椎基底动脉 3 例。VFR 和狭窄程度中度相关（r=-.670，P=.002）。狭窄动脉的平均 VFR 从 81.2 毫升/分钟增加到 133.3 毫升/分钟（P=.020）或增加了 64.2%。总脑血流量、未支架血管的血流量和 Willis 环的侧支血流量没有显著变化。
我们发现 QMRA 是一种很有前途的非侵入性方法，可用于测量颅内 Wingspan 支架置入后的脑血流动力学。需要更大的前瞻性研究来证实我们的发现。
