Correa J E, Basombrio M A, Pasqualini C D
Arch Geschwulstforsch. 1976;46(7):555-7.
Leukemogenic activity has been encountered in 100 nm filtrates of a murine leukemia virus, PLLV-T2, associated with smaller than conventional C type particles. XC plaque assay of these filtrates gave negative results, revealing a lack of correlation between in vivo and in vitro activity. It is postulated that these filtrates contain viral subunits deficient for replication in BALB fibroblasts in vitro but able to transform lymphoid cells in vivo.
在与小于传统C型颗粒相关的鼠白血病病毒PLLV-T2的100纳米滤液中发现了致白血病活性。对这些滤液进行XC空斑试验得到阴性结果，表明体内和体外活性之间缺乏相关性。据推测，这些滤液含有在体外BALB成纤维细胞中复制缺陷但能在体内转化淋巴细胞的病毒亚基。
