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对映体纯的1-芳基丙-2-烯-1-醇及其叔丁基碳酸酯的合成。

Synthesis of enantiopure 1-arylprop-2-en-1-ols and their tert-butyl carbonates.

作者信息

Stambaský Jan, Malkov Andrei V, Kocovský Pavel

机构信息

Department of Chemistry, WestChem, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

出版信息

J Org Chem. 2008 Nov 21;73(22):9148-50. doi: 10.1021/jo801874r. Epub 2008 Oct 8.

DOI:10.1021/jo801874r
PMID:18839990
Abstract

Enantiomerically pure 1-arylpropenols 8 have been prepared by resolution of the corresponding racemates, using the lipase formulation Novozyme 435. Deprotonation of the latter alcohols with n-BuLi, followed by derivatization with (t-BuO)2CO, afforded the corresponding carbonates 5. Optimization of the process is presented.

摘要

通过使用脂肪酶制剂诺维信435拆分相应的外消旋体，制备了对映体纯的1-芳基丙烯醇8。用正丁基锂使后一种醇去质子化，然后用二叔丁基碳酸酯进行衍生化，得到了相应的碳酸酯5。本文介绍了该工艺的优化。

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