心血管药物对腺苷脱氨酶活性的影响。
Effect of cardiovascular drugs on adenosine deaminase activity.
作者信息
Kowalczyk Edward, Kopff Maria, Kowalski Jan, Kopff Anna, Mikhailidis Dimitri P, Barylski Marcin, Banach Maciej
机构信息
Department of Pharmacology, Medical University of Lodz, Lodz, Poland.
出版信息
Angiology. 2008;59(6):740-4. doi: 10.1177/0003319708323495. Epub 2008 Oct 7.
OBJECTIVE
Adenosine deaminase catalyzes the conversion of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. Because raising adenosine concentration can affect several physiological processes we studied the effect of a selection of cardiological drugs on adenosine deaminase activity in red blood cells and rabbit plasma after 21 days administration.
METHODS AND RESULTS
We determined the activity of adenosine deaminase isoenzymes (ADA(1) and ADA(2)). Simvastatin, aspirin, metoprolol, and isosorbide mononitrate significantly decreased plasma total adenosine activity (by 50%, 34%, 29%, and 19%, respectively; P < .05 to P < .001) mainly by decreasing the activity of ADA(2).
CONCLUSIONS
As a consequence of decreased ADA(2) activity , the half-life of adenosine will be lengthened. This may, at least in part, explain some of the beneficial effects of analyzed drugs. Our results might be clinically relevant in patients with coronary artery disease, acute coronary syndromes, heart failure, or stroke where the investigated drugs are commonly used. However, our results should be confirmed in large studies in humans.
目的
腺苷脱氨酶分别催化腺苷和脱氧腺苷转化为肌苷和脱氧肌苷。由于提高腺苷浓度会影响多个生理过程，我们研究了连续给药21天后，几种心脏病药物对红细胞和兔血浆中腺苷脱氨酶活性的影响。
方法与结果
我们测定了腺苷脱氨酶同工酶（ADA(1)和ADA(2)）的活性。辛伐他汀、阿司匹林、美托洛尔和单硝酸异山梨酯显著降低了血浆总腺苷活性（分别降低了50%、34%、29%和19%；P <.05至P <.001），主要是通过降低ADA(2)的活性实现的。
结论
由于ADA(2)活性降低，腺苷的半衰期将延长。这可能至少部分解释了所分析药物的一些有益作用。我们的结果可能对冠状动脉疾病、急性冠状动脉综合征、心力衰竭或中风患者具有临床相关性，这些患者通常会使用所研究的药物。然而，我们的结果应在大规模人体研究中得到证实。
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