Nakamura Eitaro, Miyao Kenji
Department of Sport Sciences, Kyoto Iken College of Medicine and Health, and Department of Internal Medicine, Kyoto Second Red Cross Hospital, Nakagyo-ku, Kyoto 604-8203, Japan.
J Gerontol A Biol Sci Med Sci. 2008 Sep;63(9):936-44. doi: 10.1093/gerona/63.9.936.
This study aims to clarify sex differences in human biological aging and to explore the gender gaps in health and longevity. Eighty-six men and 93 women who received a 2-day routine health checkup for 6-7 years beginning in 1992 at the Kyoto Red Cross Hospital were selected. Five candidate biomarkers of aging (forced expiratory volume in 1.0 second per square of height [FEV(1)/Ht(2)], systolic blood pressure [SBP], red blood cells [RBC], albumin [ALBU], and blood urea nitrogen [BUN]) were selected from 29 physiological variables. Individual biological ages (BAS) were estimated from these five biomarkers by a principal component model. From the investigation of the longitudinal changes of individual BAS, it was suggested that (i) beyond 65 years, the rate of aging showed a rapid increase, and (ii) women had relatively lower functional capabilities compared with men, but the rate of aging was slower than that of men, suggesting that these differences might present both disadvantages and advantages for women with regard to health and longevity.
本研究旨在阐明人类生物衰老中的性别差异，并探讨健康和寿命方面的性别差距。选取了1992年起在京都红十字医院接受为期2天常规健康检查、持续6至7年的86名男性和93名女性。从29项生理变量中选取了5种衰老候选生物标志物（每身高平方米的1秒用力呼气量[FEV(1)/Ht(2)]、收缩压[SBP]、红细胞[RBC]、白蛋白[ALBU]和血尿素氮[BUN]）。通过主成分模型从这5种生物标志物估算个体生物年龄（BAS）。通过对个体BAS纵向变化的研究表明，（i）65岁以后，衰老速度迅速加快，以及（ii）女性与男性相比功能能力相对较低，但衰老速度比男性慢，这表明这些差异可能在健康和寿命方面给女性带来劣势和优势。
