氟喹诺酮类药物对小鼠体温的影响。
Effect of fluoroquinolones on body temperature of mice.
作者信息
Miyazaki Shuichi, Ishikawa Fumio, Matsuo Saburo, Yamaguchi Keizo
机构信息
Department of Microbiology and Infectious Disease, Toho University Faculty of Medicine School of Medicine, Tokyo, Japan.
出版信息
J Antimicrob Chemother. 2008 Dec;62(6):1319-22. doi: 10.1093/jac/dkn418. Epub 2008 Oct 7.
OBJECTIVES
The purpose of this study was to assess the effect of fluoroquinolones on rectal temperature of infected and non-infected mice.
METHODS
The effect of fluoroquinolone administration on rectal temperature was investigated in a mouse model with and without infection.
RESULTS
Hypothermia was induced by administration of gatifloxacin at doses of 1 and 10 mg/kg in non-infected mice, but not by cefditoren pivoxil. In addition, the rectal temperature was decreased in infected mice administered fluoroquinolones or cephems, a greater decrease being noted in animals receiving the former agents.
CONCLUSIONS
This study shows that fluoroquinolones decrease the rectal temperature of mice regardless of infections.
目的
本研究旨在评估氟喹诺酮类药物对感染及未感染小鼠直肠温度的影响。
方法
在感染和未感染的小鼠模型中研究氟喹诺酮类药物给药对直肠温度的影响。
结果
在未感染小鼠中，1和10mg/kg剂量的加替沙星可引起体温过低，而头孢托仑匹酯则不会。此外，给予氟喹诺酮类药物或头孢菌素的感染小鼠直肠温度降低，接受前者药物的动物体温降低幅度更大。
结论
本研究表明，无论是否感染，氟喹诺酮类药物均可降低小鼠的直肠温度。
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