银胶菊提取物对大鼠的解热潜力评估。

Evaluation of antipyretic potential of Vernonia cinerea extract in rats.

作者信息

Gupta Malaya, Mazumder U K, Manikandan L, Bhattacharya S, Haldar P K, Roy S

机构信息

Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700032, India.

出版信息

Phytother Res. 2003 Aug;17(7):804-6. doi: 10.1002/ptr.1230.

DOI:10.1002/ptr.1230

PMID:12916082

Abstract

The methanol extract of the whole plant of Vernonia cinerea (MEVC) was evaluated for its antipyretic potential on normal body temperature and yeast-induced pyrexia in rats. MEVC significantly reduced the normal body temperature at doses of 250 and 500 mg/kg body weight p.o. MEVC also lowered the elevated body temperature in the case of yeast-induced pyrexia in a dose dependent manner. The antipyretic effect of the extract at a dose of 500 mg/kg was identical to that of the standard drug paracetamol.

摘要

对灰叶斑鸠菊全草的甲醇提取物（MEVC）在大鼠正常体温和酵母诱导发热模型上的解热潜力进行了评估。口服给予MEVC 250和500 mg/kg体重剂量时，可显著降低正常体温。在酵母诱导发热的情况下，MEVC也能以剂量依赖的方式降低体温升高。提取物500 mg/kg剂量的解热作用与标准药物对乙酰氨基酚相同。