Jellicoe Paul, Hopyan Sevan
Division of Pediatric Orthopaedics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
J Pediatr Orthop B. 2008 Nov;17(6):329-32. doi: 10.1097/BPB.0b013e32830cc390.
Chronic recurrent multifocal osteomyelitis (CRMO) and B-cell lymphoma are fairly uncommon conditions that are seen in children. Although CRMO can leave patients with residual deformities and disabilities, it is a benign condition. We describe an unusual situation in which a site adjacent to a biopsy-documented site of CRMO presented 3.5 years later with B-cell lymphoma. B-cell lymphoma can behave in an indolent manner and reports suggest that this condition can initially be mistaken for CRMO. This case presented here underscores the importance of vigilance in the short and long-term management of patients initially diagnosed with CRMO, and raises the possibility that the pathogenesis of the two conditions is related.
慢性复发性多灶性骨髓炎（CRMO）和B细胞淋巴瘤在儿童中较为罕见。尽管CRMO会使患者留下残余畸形和残疾，但它是一种良性疾病。我们描述了一种不寻常的情况，在一个经活检证实的CRMO部位附近，3.5年后出现了B细胞淋巴瘤。B细胞淋巴瘤可能呈惰性表现，有报告表明这种疾病最初可能被误诊为CRMO。本文所述病例强调了在对最初诊断为CRMO的患者进行短期和长期管理时保持警惕的重要性，并提出了这两种疾病的发病机制可能相关的可能性。
