Hangai Mayumi, Watanabe Kentaro, Shiozawa Ryosuke, Hiwatari Mitsuteru, Ida Kohmei, Takita Junko
Department of Pediatrics, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Oncol Lett. 2014 Apr;7(4):991-993. doi: 10.3892/ol.2014.1820. Epub 2014 Jan 23.
The present study describes a unique pediatric case with multiple bone invasions of acute lymphoblastic leukemia (ALL) during remission. An eight-year-old male with a history of ALL was admitted complaining of intermittent and migrating pain in the limb 2 years following complete remission. Magnetic resonance imaging and whole-body positron emission tomography with F-fluorodeoxyglucose revealed abnormal multifocal involvement in the bones and corresponding soft tissues. Repeated bone marrow (BM) aspiration indicated normal cellular marrow without leukemic cells, and marked leukemic cell infiltration in different sections of the ilium, respectively. These findings suggested isolated bone relapse, and it is probable that systematic BM relapse occurred as a consequence.
本研究描述了一例独特的小儿急性淋巴细胞白血病（ALL）缓解期多发骨浸润病例。一名有ALL病史的8岁男性在完全缓解2年后因四肢间歇性游走性疼痛入院。磁共振成像和F-氟脱氧葡萄糖全身正电子发射断层扫描显示骨骼及相应软组织存在多灶性异常受累。多次骨髓穿刺显示细胞骨髓正常，无白血病细胞，但分别在髂骨不同部位有明显的白血病细胞浸润。这些发现提示为孤立性骨复发，随后很可能发生系统性骨髓复发。
